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凌晨副教授

邮  箱:cling@xmu.edu.cn

职称/职务:副教授

联系方式:

  • 个人简介
  • 科研领域
  • 代表性成果

2014年,中国农业大学生物科学专业,学士学位;
2019年,beat365官方网站大学生物学专业,博士学位;
2019-2023年,美国可再生能源国家实验室(NREL),博士后;
2023年,beat365官方网站,副教授
B.S. China Agriculture University, College of Biological Sciences, 2010-2014;
Ph.D. 2019, Tsinghua University, School of Life Sciences, 2014-2019;
Postdoctoral Fellow, National Renewable Energy Laboratory, 2019-2023;
Associate Professor, School of Life Sciences, Xiamen University, starting from 2023.

凌晨于2019年在beat365官方网站取得生物学博士学位,导师陈国强教授。在beat365官方网站,凌晨的主要工作为嗜盐菌中的代谢工程改造,利用可再生原料生产生物材料聚羟基脂肪酸酯(PHA);以及在嗜盐菌中开发CRISPR/Cas9基因编辑工具。2019年至2023年在美国可再生能源国家实验室(National Renewable Energy Laboratory)和美国能源部敏捷生物铸造(Agile BioFoundry)从事博士后研究工作,合作导师Gregg Beckham博士。主要研究方向为利用假单胞菌Pseudomonas putida KT2440实现木质纤维素水解物到高附加值化合物(粘康酸)和生物材料(PHA)的转化,以第一作者在Nat. Commun., Metab. Eng., Biotechnol. Bioeng.等国际主流学术刊物上发表研究论文,并取得中国和美国相关专利。相关专利均实现转化。在beat365官方网站,凌晨实验室将聚焦两个研究领域:1)在工业微生物(比如盐单胞菌,假单胞菌,和发酵单胞菌)中构建一碳代谢,实现利用甲醇,甲酸和CO2作为原料来合成化合物;2)在微生物中利用代谢工程等合成生物学方法,将可再生原料转化为各类化合物,比如PHA,乙醇和可再生航空燃料。
Dr. Chen Ling received his PhD from Tsinghua University in 2019, under the supervision by Prof. Guo-Qiang Chen. At Tsinghua, Chen mainly worked on metabolic engineering and developing CRISPR/Cas9-related tools in Halomonas sp., to produce biomaterial polyhydroxyalknoates (PHAs). He joined National Renewable Energy Laboratory (USA) as a postdoctoral researcher in 2019. At NREL, Chen worked with Dr. Gregg Beckham on Agile BioFoundry projects, to produce value-added compounds and performance advantaged materials in Pseudomonas putida from lignocellulose hydrolysates. Chen has 8 peer-reviewed publications, and he is among the inventors lists of both China and US patents relating to applied biotechnology. The patents he contributed to have both been licensed to industrial partners. Based on his experience, the Ling Lab will focus on two research areas at Xiamen University: 1) Engineering the one carbon metabolism into industrial relevant bacterial strains (Halomonas sp., Pseudomonas sp., and Zymomonas mobilis), to achieve biochemicals production from methanol, formic acid, and CO2; 2) Metabolic engineering of microbes to efficiently utilize renewable carbon resources, to produce sustainable bioproducts, including PHA, ethanol, and sustainable aviation fuel (SAF).

代表性论文(# co-first author, * Corresponding author):

1. Chen Ling, George L. Peabody, Davinia Salvachúa, Young-Mo Kim, Colin M. Kneucker, Christopher H. Calvey, Michela A. Monninger, Nathalie Munoz Munoz, Brenton C. Poirier, Kelsey J. Ramirez, Peter C. St. John, Sean P. Woodworth, Jon K. Magnuson, Kristin E. Burnum-Johnson, Adam M. Guss*, Christopher W. Johnson* & Gregg T. Beckham*. Muconic acid production from glucose and xylose in Pseudomonas putida via evolution and metabolic engineering. Nature Communications, 2022. 13(1): 1-14.
2. Chen Ling, Guan-Qing Qiao, Bo-Wen Shuai, Karel Olavarria, Jin Yin, Rui-Juan Xiang, Kun-Nan Song, Yun-Hao Shen, Yingying Guo*, Guo-Qiang Chen*. Engineering NADH/NAD+ ratio in Halomonas bluephagenesis for enhanced production of polyhydroxyalkanoates (PHA). Metabolic Engineering, 2018, 49: 275-286.
3. Chen Ling#, Guan-Qing Qiao#, Bo-Wen Shuai#, Kun-Nan Song, Wen-Xi Yao, Xiao-Ran Jiang*, Guo-Qiang Chen*. Engineering self-flocculating Halomonas campaniensis for wastewaterless open and continuous fermentation. Biotechnology and Bioengineering, 2019, 116(4): 805-815.
4. Robin Cywar#, Chen Ling#, Ryan Clarke, Donghyun Kim, Colin Kneucker, Davinia Salvachúa, Shu Xu, Meltem Urgun Demirtas, Bennett Addison, Nicholas Rorrer, Christopher W. Johnson, Robert Allen, Eugene Y.-X. Chen*, Gregg T. Beckham*. Biodegradable and reprocessable thermosets from microbially-produced unsaturated polyhydroxyalkanoates. Science Advances, Under review.
5. Ying Wang, Chen Ling, Yong Chen, Xiao-Ran Jiang, Guo-Qiang Chen*. Microbial engineering for easy downstream processing. Biotechnology Advances, 2019. 37(6): 107365.
6. Qin Qin, Chen Ling, Yiqing Zhao, Tian Yang, Jin Yin, Yingying Guo*, Guo-Qiang Chen*. CRISPR/Cas9 editing genome of extremophile Halomonas spp. Metabolic Engineering, 2018, 47: 219-229.
7. Yilin Ren, Chen Ling, Ivan Hajnal, Qiong Wu, Guo-Qiang Chen*. Construction of Halomonas bluephagenesis capable of high cell density growth for efficient PHA production. Applied Microbiology and Biotechnology, 2018, 102 (10): 4499-4510.
8. Haitao Yue, Chen Ling, Tao Yang, Xiangbin Chen, Yuling Chen, Haiteng Deng, Qiong Wu, Jinchun Chen, Guo-Qiang Chen*. A seawater-based open and continuous process for polyhydroxyalkanoates production by recombinant Halomonas campaniensis LS21 grown in mixed substrates. Biotechnology for Biofuels, 2014, 7(1): 108.

荣誉、奖励及参加学术团体的情况:

Key Contributor Award, National Bioenergy Center, NREL (2023)
北京市优秀毕业生(2019)