2010-2014年，beat365官方网站生物科学专业，学士学位；
2014-2019年，beat365官方网站生物学专业，博士学位；
2019-2020年，西湖大学，助理研究员；
2021-2023年，西湖大学，博士后；
2023年，beat365官方网站，副教授
B.S. 2010-2014, Xiamen University, Biological Science;
Ph.D., 2014-2019, Tsinghua University, Biology;
Research assistant, 2019-2020, Westlake University;
Postdoctoral Fellow, 2021-2023, Westlake University;
Associate Professor, 2023-Present, School of Life Sciences, Xiamen University.

主要从事重要膜蛋白以及蛋白复合物的冷冻电镜结构解析和功能机制研究工作。一方面发挥在膜蛋白表达提纯和冷冻电镜样品制备的优势，开展人类重大疾病特别是神经系统疾病相关膜蛋白的结构解析和调控机制研究；另一方面借力本院在细胞生物学和生物化学上的优势，开展合作课题研究，从结构生物学角度解释细胞应激调控机制，助力新型药物的研发和推广。
We mainly focus on structural analysis and functional mechanism research of membrane proteins and protein complexes by cryo-electron microscopy. On the one hand, we utilize our strengths in membrane protein purification and sample preparation to explore the structures and regulatory mechanisms of membrane proteins related to major human diseases, especially neurological diseases; on the other hand, we will collaborate with other scientists to explain structure mechanisms of cellular stress biology, and facilitate the development of novel drugs.

代表性论文(^# co-first author, ^* Corresponding author):

[1] Gong D^#,^*, Chi X^#, Wei J^#, Zhou G, Huang G, Zhang L, Wang R, Lei J, Chen SRW^*, Yan N^*. Modulation of cardiac ryanodine receptor 2 by calmodulin. Nature, 2019, 572: 347-351, doi:10.1038/s41586-019-1377-y
[2] Chi X^#, Li X^#, Chen Y^#, Zhang Y, Su Q, Zhou Q^*. Cryo-EM structures of the full-length human KCC2 and KCC3 cation-chloride cotransporters. Cell Res, 2021, 31: 482-484, doi:10.1038/s41422-020-00437-x
[3] Chi X^#, Fan Q^#, Zhang Y^#, Liang K, Wan L, Zhou Q^*, Li Y^*. Structural mechanism of phospholipids translocation by MlaFEDB complex. Cell Res, 2020, 30: 1127-1135, doi:10.1038/s41422-020-00404-6
[4] Chi X^#, Gong D^#,^*, Ren K, Zhou G, Huang G, Lei J, Zhou Q, Yan N^*. Molecular basis for allosteric regulation of the type 2 ryanodine receptor channel gating by key modulators. Proc Natl Acad Sci U S A, 2019, 116: 25575-25582, doi:10.1073/pnas.1914451116
[5] Gong D^#, Chi X^#, Ren K^#, Huang G, Zhou G, Yan N, Lei J, Zhou Q^*. Structure of the human plasma membrane Ca2+-ATPase 1 in complex with its obligatory subunit neuroplastin. Nat Commun, 2018, 9: 3623, doi:10.1038/s41467-018-06075-7
[6] Xie T^#, Chi X^#, Huang B, Ye F, Zhou Q^*, Huang J^*. Rational exploration of fold atlas for human solute carrier proteins. Structure, 2022, 10.1016/j.str.2022.05.015
[7] Chi X^#, Jin X^#, Chen Y^#, Lu X^#, Tu X, Li X, Zhang Y, Lei J, Huang J, Huang Z^*, Zhou Q^*, Pan X^*. Structural insights into the gating mechanism of human SLC26A9 mediated by its C-terminal sequence. Cell Discov, 2020, 6: 55, doi:10.1038/s41421-020-00193-7
[8] Chi X^#, Xia L^#, Zhang G^#, Chi X^#, Huang B^#, Zhang Y^#, Chen Z^#, Han J, Wu L, Li Z, Sun H, Huang P, Yu C^*, Chen W^*, Zhou Q^*. Comprehensive structural analysis reveals broad-spectrum neutralizing antibodies against sars-cov-2 omicron variants. Cell Discov, 2023, 9: 37, doi:10.1038/s41421-023-00535-1

荣誉、奖励及参加学术团体的情况: