2002年，中国农业大学生物科学专业，学士学位；
2007年，中国农业大学生物化学与分子生物学专业，理学博士学位；
2007-2012年，美国国立卫生研究院，博士后；
2012年至今，beat365官方网站教授，福建省闽江学者特聘教授；
2012年获美国国立卫生研究院院长奖（NIH Director’s Awards）；
2014年获863青年科学家资助；
2015年获国家自然基金优秀青年基金资助；
2023年入选教育部长江学者奖励计划。
B.S. 2002, China Agricultural University, Biology;
Ph.D. 2007, China Agricultural University, Biochemistry and Molecular Biology;
Postdoctoral Fellow, National Institutes of Health, 2007-2012;
Professor, School of Life Science, Xiamen University, 2012-Present.

疟疾是寄生性原生动物---疟原虫感染导致的传染性疾病，每年导致数亿人口感染和约50万人死亡。由于缺乏高效疟疾疫苗，加之疟原虫耐药，疟疾的全球防控依然面临巨大挑战。疟原虫生活周期（生活史）复杂，在两个截然不同的宿主-按蚊和脊椎动物之间交替寄生。课题组专注疟原虫双宿主寄生的适应性机制，揭示疟原虫宿主寄生和宿主转换的遗传和分子机制，为阻断疟原虫感染、寄生和传播提供新策略，为疟疾药物和疫苗设计提供新标靶。
课题组研究方向包括：
1. 疟原虫按蚊传播中感染和寄生的分子细胞机制。
疟原虫是单细胞真核生物，在雌性按蚊和脊椎动物动物两个宿主间交替传播，经历不同细胞阶段和显著差别的细胞形态和细胞功能。疟原虫如何在不同宿主阶段完成感染，寄生和传播？我们以鼠疟原虫-小鼠-按蚊为模型，重点关注疟原虫有性生殖的如下过程：
配子体形成；配子体激活成为配子（配子发生）；雌雄配子受精成为合子；合子（受精卵）变形为动合子；动合子获能穿越按蚊消化道上皮；动合子转化成卵囊。
2. 开发和优化基因组修饰工具CRISPR/Cas9，提高疟原虫基因功能解析的效率。
近三年以通讯作者在《Science Advances》、《PNAS》、《EMBO Journal》、《Nature Communications》、《Current Biology》、《EMBO Reports》、《mBio》等杂志发表多篇论文，上述文章第一作者均为课题组研究生。欢迎加入我们的团队。

代表性论文(^# co-first author, ^* Corresponding author):

1. Shuzhen Yang^#, Mengya Cai^#, Junjie Huang^#, Shengnan Zhang, Xiaoli Mo,Kai Jiang^*, Huiting Cui^*, Jing Yuan^*, EB1 decoration of microtubule lattice facilitates spindle-kinetochore lateral attachment in Plasmodium male gametogenesis. Nature Communications, 2023, 14(2864)
2. Pengge Qian^#, Xu Wang^#, Cuirong Guan^#, Xin Fang, Mengya Cai, Chuan-qi Zhong, Yong Cui, Yanbin Li, Luming Yao, Huiting Cui^*, Kai Jiang^*, Jing Yuan^*, Apical anchorage and stabilization of subpellicular microtubules by apical polar ring ensures Plasmodium ookinete infection in mosquito. Nature Communications, 2022, 13(7465)
3. Pengge Qian^#, Xu Wang^#, Chuan-Qi Zhong^#, Jiaxu Wang, Mengya Cai, Wang Nguitragool, Jian Li^*, Huiting Cui^*, Jing Yuan^*, Inner membrane complex proteomics reveals a palmitoylation regulation critical for intraerythrocytic development of malaria parasite. eLife,2022,11(e77447)
4. Meng Liu^#, Gangqiang Guo^#, Pengge Qian^#, Jianbing Mu^#, Binbin Lu, Xiaoqin He, Yanting Fan, Xiaomin Shang, Guang Yang, Shijun Shen, Wenju Liu, Liping Wang, Liang Gu, Quankai Mu, Xinyu Yu, Yuemeng Zhao, Richard Culleton, Jun Cao, Lubin Jiang, Thomas E. Wellems^*, Jing Yuan^*, Cizhong Jiang^*,Qingfeng Zhang^*, 5-methylcytosine modification by Plasmodium NSUN2 stabilizes mRNA and mediates the development of gametocytes. PNAS, 2022, 119(9)
5. Zhenke Yang^#, Yang Shi ^#, Huiting Cui ^#, Shuzhen Yang, Han Gao, Jing Yuan^*. A malaria parasite phospholipid flippase safeguards midgut traversal of ookinetes for mosquito transmission. Science Advances, 2021,eabf6015
6. Zhenkui Li^#, Huiting Cui^#, Jiepeng Guan, Cong Liu, Zhengang Yang, Jing Yuan^*. Plasmodium transcription repressor AP2-O3 regulates sex-specific identity of gene expression in female gametocytes. EMBO Reports, 2021, e51660: 1-18
7. Xu Wang^#, Pengge Qian^#, Huiting Cui^#, Luming Yao, Jing Yuan^*. A Protein Palmitoylation Cascade Regulates Microtubule Cytoskeleton Integrity in Plasmoidum. EMBO Journal, 2020, 39(13)
8. YuanYuan Jiang^#, Jun Wei^#, Huiting Cui^#, Chuanyuan Liu, Yuan Zhi, ZhengZheng Jiang, Zhenkui Li, Shaoneng Li, Zhenke Yang, Xu Wang, Pengge Qian, Cui Zhang, Chuanqi Zhong, Xin-zhuan Su, Jing Yuan^*. An intracellular membrane protein GEP1 regulates xanthurenic acid induced gametogenesis of malaria parasites. Nature Communications, 2020, 11(1)
9. Gao H^#, Yang Z^#, Wang X^#, Qian P, Hong R, Chen X, Su XZ, Cui H, Yuan J^*. ISP1-anchored Polarization of GCβ/CDC50A Complex Initiates Malaria Ookinete Gliding Motility. Current Biology, 2018, 28(17): 2763-2776
10. Zhang C^#, Li Z^#, Cui H^#, Jiang Y, Yang Z, Wang X, Gao H, Liu C, Zhang S, Su XZ^*, Yuan J^*. Systematic CRISPR-Cas9-Mediated Modifications of Plasmodium yoelii ApiAP2 Genes Reveal Functional Insights into Parasite Development. mBio, 2017, 8(6):e01986-17
11. Zhang C^#, Xiao B^#, Jiang Y^#, Zhao Y^#, Li Z, Gao H, Ling Y, Wei J, Li S, Lu M, Su XZ, Cui H^*, Yuan J^*. Efficient Editing of Malaria Parasite Genome Using the CRISPR/Cas9 System. mBio, 2014, 5(4): 01414-14
12. Chuanyuan Liu^#; Zhenke Yang^#; Mengya Cai; Yang Shi; Huiting Cui; Jing Yuan^*. Generation of Plasmodium yoelii malaria parasite for conditional degradation of proteins. Mol Biochem Parasitol, 2021, 241(111346)
13. Liu C^#, Li Z^#, Jiang Y, Cui H^*, Yuan J^*. Generation of Plasmodium yoelii malaria parasite carrying double fluorescence reporters in gametocytes. Mol Biochem Parasitol, 2018, 224: 37-43
14. Qian P^#, Wang X^#, Yang Z, Li Z, Gao H, Su XZ, Cui H^*, Yuan J^*. A Cas9 transgenic Plasmodium yoelii parasite for efficient gene editing. Mol Biochem Parasitol, 2018, 222:21-28
15. Zhang C^#, Gao H^#, Yang Z, Jiang Y, Li Z, Wang X, Xiao B, Su XZ, Cui H^*, Yuan J^*. CRISPR/Cas9 mediated sequential editing of genes critical for ookinete motility in Plasmodium yoelii. Mol Biochem Parasitol, 2016, 212:1-8
16. Yuan J^#, Cheng KC^#, Johnson RL, Huang R, Pattaradilokrat S, Liu A, Guha R, Fidock DA, Inglese J, Wellems TE, Austin CP^*, Su XZ^*. Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets. Science, 2011, 333:724-729. ( Research article and Cover story; Rated “Exceptional” 10.0 by Faculty of 1000)
17. Yuan J, Johnson RL, Huang R, Wichterman J, Jiang H, Hayton K, Fidock DA, Wellems TE, Inglese J, Austin CP, Su XZ. Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Nature chemical biology, 2009, 5(10):765-771.

荣誉、奖励及参加学术团体的情况:

福建省高校青年教师教学竞赛二等奖，2018
beat365官方网站“何宜慈讲座教授奖教金”，2021
beat365官方网站“我最喜爱的十位老师”，2020
beat365官方网站第十二届青年教师教学技能比赛特等奖，2017
美国国立卫生研究院院长奖（NIH Director’s Awards），2012

主持项目：
2015年获国家自然科学基金优青项目资助
2021年获国家自然科学基金面上项目资助
2019年获国家自然科学基金面上项目资助
2017年获国家自然科学基金面上项目资助
2015年获科技部863青年科学家专题资助
2014年获国家自然科学基金青年项目资助